Glivec 400mg Tablet
Glivec 400mg Tablet belongs to the class of medicines known as tyrosine kinase inhibitors. It is used in the treatment of blood cancer (chronic myeloid leukaemia and Acute lymphocytic leukemia) and gastrointestinal stromal tumor. Glivec 400mg Tablet should be taken with food, but better to have it same time every day to get the most benefit. You should continue to take it as long as your doctor advises for it. The duration of treatment varies according to your need and response to treatment. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to. The most common side effects of this medicine include edema, nausea, vomiting, muscle cramps, musculoskeletal pain, diarrhea, rash, fatigue, and abdominal pain. Let your doctor know if you experience unexpected rapid weight gain. Your doctor may advise for regular monitoring of blood cells and liver function while you are taking this medicine. Do not drive or do anything requiring mental focus if you experience dizziness and blurry vision. Many other medicines can affect, or be affected by, this medicine so let your healthcare team know all medications you are using. This medicine is not recommended during pregnancy or while breastfeeding. The use of effective contraception by both males and females during treatment is important to avoid pregnancy.
Written by: Radhika B Shiraguppi, B. Pharma
Reviewed by: Dr. Jay Faldu, MBBS
Last updated on: 21-04-2025
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More About Glivec 400mg Tablet
Quick Summary
Glivec 400mg Tablet belongs to the class of medicines known as tyrosine kinase inhibitors. It is used in the treatment of blood cancer (chronic myeloid leukaemia and Acute lymphocytic leukemia) and gastrointestinal stromal tumor. Glivec 400mg Tablet should be taken with food, but better to have it same time every day to get the most benefit. You should continue to take it as long as your doctor advises for it. The duration of treatment varies according to your need and response to treatment. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to. The most common side effects of this medicine include edema, nausea, vomiting, muscle cramps, musculoskeletal pain, diarrhea, rash, fatigue, and abdominal pain. Let your doctor know if you experience unexpected rapid weight gain. Your doctor may advise for regular monitoring of blood cells and liver function while you are taking this medicine. Do not drive or do anything requiring mental focus if you experience dizziness and blurry vision. Many other medicines can affect, or be affected by, this medicine so let your healthcare team know all medications you are using. This medicine is not recommended during pregnancy or while breastfeeding. The use of effective contraception by both males and females during treatment is important to avoid pregnancy.
Benefits of Glivec 400mg Tablet
Blood cancer (Chronic myeloid leukaemia) / Blood cancer (Acute lymphocytic leukemia) / Gastrointestinal stromal tumour
In Blood cancer (Chronic myeloid leukaemia) Blood cancer, also called leukemia, is a cancer of the blood-forming tissues, that decreases the body's ability to fight infection. Glivec 400mg Tablet kills or stops the growth of cancer cells and also prevents the multiplication of cancer cells. It is a potent and very toxic medicine and you should discuss the risks and benefits with your doctor. You should avoid drinking alcohol while having this treatment and drink plenty of water to stay hydrated. In Blood cancer (Acute lymphocytic leukemia) Blood cancer, also called leukemia, is a cancer of the blood-forming tissues, that decreases the body's ability to fight infection. Glivec 400mg Tablet kills or stops the growth of cancer cells and also prevents the multiplication of cancer cells. It is a potent and very toxic medicine and you should discuss the risks and benefits with your doctor. You should avoid drinking alcohol while having this treatment and drink plenty of water to stay hydrated. In Gastrointestinal stromal tumour A gastrointestinal stromal tumor (GIST) is a type of tumor that occurs most commonly in the stomach or small intestine. The tumors develop into the specialized cells called interstitial cells of Cajal (ICCs). Glivec 400mg Tablet helps to kill the cancer cells and also stops their further growth and spread. Follow your doctor?s instructions carefully to get the most benefit.
Side Effects of Glivec 400mg Tablet
The majority of side effects typically do not necessitate medical intervention. and disappear as your body adjusts to the medicine. Doctor consultation is advised if they persist or if you're worried about them. ['Nausea, Vomiting, Muscle cramp, Musculoskeletal (bone, muscle or joint) pain, Diarrhea, Rash, Fatigue, Abdominal pain']
Directions for Use
Follow your doctor's guidance regarding the dose and duration of this medication. Ingest it without breaking or crushing. Do not chew, crush or break it. Glivec 400mg Tablet is to be taken with food.
How it works
Glivec 400mg Tablet is an anti-cancer medication. A protein enzyme, bcr-abl tyrosine kinase, responsible for the growth of abnormal proliferation of cancer cells. This medicine inhibits the proliferation and induces apoptosis (planned cell death) in bcr-abl positive cells (cancer cells). This is how it works to stop or slow the spread of cancer.
Alcohol
Consult your Doctor: Please consult your doctor regarding the safety of consuming alcohol with Glivec 400mg Tablet . Experts have not found evidence of alcohol impairing the effectiveness of the medicine.
Pregnancy
Seek medical advice from your doctor: Glivec 400mg Tablet is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Doctor consultation is advised.
Breast feeding
Seek medical advice from your doctor: Glivec 400mg Tablet is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby. Lactating women should not breastfeed while using this drug and one month after stopping it.
Driving
Not Safe: Glivec 400mg Tablet may cause side effects which could affect your ability to drive.
Kidney
Caution Advised: Glivec 400mg Tablet should be used with caution in patients with kidney disease. Dose adjustment of Glivec 400mg Tablet may be needed. Doctor consultation is advised.
Liver
Caution Advised: Glivec 400mg Tablet should be used with caution in patients with severe liver disease. Dose adjustment of Glivec 400mg Tablet may be needed. Doctor consultation is advised.
What If You Forget to take Glivec 400mg Tablet?
If you forget a dose of Glivec 400mg Tablet , simply continue with your regular schedule and do not take a double dose.
Storage Advice
Store in a cool and dry place, and keep the temperature below 30�C
Quick Tips for Glivec 400mg Tablet
Always take�it with food and a full glass of water to prevent nausea. It�may cause dizziness or blurred vision. Do not drive or do anything requiring concentration until you know how it affects you. Water retention and swelling are very common side effects of Glivec 400mg Tablet. Notify your doctor if you have unexpected rapid weight gain. Do not change the dose or discontinue use without consulting your doctor. Notify your doctor about all the medications you are taking, including over the counter medicines and dietary supplements. Your doctor may get regular blood tests done to monitor your liver function and the number of blood cells in your blood.
Manufacturer Address
Sandoz House, Shiv Sagar Estate, Worli Mumbai -400 018, India
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