Segirab AD 200mg/20mg Tablet SR

Segirab AD 200mg/20mg Tablet SR provides a dual-action approach to managing chronic inflammatory conditions while prioritising gastrointestinal safety.

Aceclofenac is a phenylacetic acid derivative with potent anti-inflammatory and analgesic properties. It acts by inhibiting the cyclooxygenase (COX) enzyme, thereby blocking the synthesis of prostaglandins (the chemical mediators responsible for pain, heat, and swelling at the site of injury or disease). While effective for joint health, the systemic reduction of prostaglandins can leave the stomach lining vulnerable to gastric acid.

Rabeprazole is included to mitigate these gastric risks. As a substituted benzimidazole proton pump inhibitor, it suppresses gastric acid secretion by inhibiting the H⁺/K⁺-ATPase enzyme at the secretory surface of the gastric parietal cell. By providing a sustained increase in gastric pH, Rabeprazole helps prevent the formation of erosions and ulcers that may otherwise occur during long-term Aceclofenac therapy.

Both medications are absorbed through the gastrointestinal tract. Aceclofenac is primarily metabolised by the liver, while Rabeprazole undergoes extensive hepatic metabolism via cytochrome P450 enzymes. This combination is designed for patients who require effective pain management but have a history of gastric sensitivity or other risk factors for NSAID-induced ulcers.

Osteoarthritis

For the relief of pain and inflammation associated with degenerative joint disease.

Rheumatoid Arthritis

For the management of swelling, stiffness, and joint pain in autoimmune-related arthritis.

Ankylosing Spondylitis

For the treatment of inflammatory pain affecting the spine and sacroiliac joints.

Chronic Pain Management

For patients requiring long-term NSAID therapy who are at high risk for gastric complications.

Post-Traumatic Pain

For the management of inflammation following significant musculoskeletal injuries.

Dental Pain

Effective in reducing toothache and pain following dental procedures, while minimising stomach irritation from NSAID use.

• Integrated Gastric Protection: The built-in Rabeprazole component helps shield the stomach lining from the irritating effects of the pain reliever.

• Effective Inflammation Control: Aceclofenac provides targeted relief for joint stiffness and swelling, helping to restore mobility.

• Convenience: Combining two different therapeutic classes into a single dose simplifies the daily medication schedule.

• Reduced Ulcer Risk: This combination is formulated to decrease the likelihood of developing NSAID-induced gastric or duodenal ulcers.

• Sustained Action: Often available in formulations that allow for consistent drug levels in the blood, providing relief throughout the day.

Segirab AD 200mg/20mg Tablet SR may cause side effects. Many people using this medication do not have serious side effects. Seek medical help if you experience any persistent or severe symptoms.

Common Side Effects

• You should check with your doctor if any of these symptoms are severe or do not go away:

• Dizziness or a spinning sensation

• Nausea, gas, or mild stomach pain

• Diarrhoea or constipation

• Headache

• Feeling tired or sleepy

Uncommon Side Effects

• Contact your doctor if you experience:

• Loss of appetite

• Itching or a mild skin rash

• Swelling in your legs or feet

• Ringing in your ears

• Changes in your sense of taste

Serious Side Effects (Require Immediate Medical Attention)

• Call your doctor at once if you have:

• Signs of stomach bleeding: Black, bloody, or tarry stools; coughing up blood or vomit that looks like coffee grounds.

• Kidney problems: Little or no urination; painful or difficult urination; swelling in your feet or ankles.

• Liver problems: Nausea, upper stomach pain, itching, tired feeling, loss of appetite, dark urine, or yellowing of the skin or eyes.

• Severe skin reaction: Fever, sore throat, swelling in your face or tongue, burning in your eyes, skin pain followed by a red or purple skin rash that spreads.

• Low magnesium: Dizziness, fast or irregular heart rate, tremors, or muscle cramps.

Segirab AD 200mg/20mg Tablet SR should be taken exactly as directed by your doctor. It is recommended to take it before a meal, as Rabeprazole works most effectively when taken 15 to 30 minutes before eating, allowing it to inhibit active proton pumps stimulated by food. Do not crush, chew, or break the tablet, as this may interfere with the enteric coating or modified-release properties of Rabeprazole. Use the lowest effective dose for the shortest duration necessary to control symptoms. Do not exceed the prescribed dose, and inform your doctor if pain or gastrointestinal symptoms worsen during treatment.

Segirab AD 200mg/20mg Tablet SR works by targeting both the source of pain and the potential for stomach irritation. Aceclofenac stops the body from producing prostaglandins, which are the chemicals that cause your joints to feel painful and swollen. While this helps your joints, it can lead to more acid irritation in the stomach. Rabeprazole works by shutting down the "proton pumps" in your stomach cells that produce acid. By reducing the overall acidity of your stomach, it helps protect the lining from damage, while Aceclofenac addresses the inflammation.

• Consistency is Key: Take your dose at the same time each morning to help maintain stable levels in your body.

• Empty Stomach: For best results, take the dose 30 minutes before your first meal to allow the Rabeprazole to activate correctly.

• Watch for Bleeding: Tell your doctor if you have symptoms of an ulcer, such as stomach pain that gets worse after eating or at night.

• Stay Hydrated: Drinking plenty of fluids can help support your kidneys while you are taking an NSAID.

• Check Your Meds: Before taking any over-the-counter medicine for cold, allergy, or pain, ask your doctor or pharmacist if it is safe to use with Segirab AD 200mg/20mg Tablet SR.

• Report New Rashes: Even a mild skin rash can be a sign of a serious reaction; notify your healthcare provider immediately if one appears.

• Alcohol: Avoid alcohol, as it significantly increases the risk of severe stomach bleeding and may enhance dizziness.
• High-Fat Meals: Taking the medicine with a very high-fat meal may delay the absorption of the ingredients, though it may be taken with light food if stomach upset occurs.
• Caffeine: Large amounts of caffeine may increase stomach acid and counteract the benefits of Rabeprazole.

Tell your doctor about all your current medicines. Many drugs can interact with Segirab AD 200mg/20mg Tablet SR, especially:

• Blood thinners such as Warfarin (Coumadin, Jantoven).

• Diuretics or "water pills."

• Lithium or other mood stabilisers.

• Methotrexate (used to treat cancer or rheumatoid arthritis).

• Steroid medicines such as Prednisone.

• Heart or blood pressure medicines, including ACE inhibitors.

• Heart Disease: NSAIDs may increase the risk of serious heart or circulatory problems, including heart attack or stroke.

• Asthma: This medicine may cause a severe allergic reaction in people with aspirin-sensitive asthma.

• History of Ulcers: Use with caution if you have ever had a stomach or intestinal ulcer or gastrointestinal bleeding.

• Lupus: People with certain autoimmune disorders may have a higher risk of serious side effects.

If you miss a dose, take it as soon as you remember. If it is almost time for your next scheduled dose, skip the missed dose and continue with your regular schedule. Never take two doses at the same time to compensate for a missed one. If you frequently miss doses, consult your healthcare provider, as consistent dosing is important for sustained pain control and continuous gastroprotection.