Zypentin 400mg/10mg Tablet
Zypentin 400mg/10mg Tablet is a combination medicine used for the treatment of neuropathic pain. This medicine decreases the pain by stopping the movement of pain signals to the brain. Zypentin 400mg/10mg Tablet is taken by mouth, with or without food and preferably at night. It is advised to take it at a fixed time each day to maintain a consistent level of medicine in the blood. In case you miss a dose of this medicine, take it as soon as you remember. Finish the full course of treatment even if you feel better. It is important not to stop taking this medicine suddenly without talking to the doctor as it may worsen your symptoms. Some common side effects of this medicine constipation, difficulty in urination, weight gain, tiredness, and dryness in mouth. It may also cause dizziness and sleepiness, so do not drive or do anything that requires mental focus until you know how this medicine affects you. This medicine may cause weight gain and to control it, you should exercise regularly and take a balanced diet. Remember to inform the doctor if you develop any unusual changes in mood as this medicine may lead to suicidal thoughts. Before taking this medicine let your doctor know if you suffer from kidney or liver disease. Your doctor should also know about all other medicines you are taking as many of these may make this medicine less effective or change the way it works. Inform your doctor if you are pregnant, planning pregnancy or breastfeeding.
Written by: Syed Jommy Abbas, B. Pharma
Reviewed by: Dr. Devika Rani, MBBS
Last updated on: 17-04-2025
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More About Zypentin 400mg/10mg Tablet
Quick Summary
Zypentin 400mg/10mg Tablet is a combination medicine used for the treatment of neuropathic pain. This medicine decreases the pain by stopping the movement of pain signals to the brain. Zypentin 400mg/10mg Tablet is taken by mouth, with or without food and preferably at night. It is advised to take it at a fixed time each day to maintain a consistent level of medicine in the blood. In case you miss a dose of this medicine, take it as soon as you remember. Finish the full course of treatment even if you feel better. It is important not to stop taking this medicine suddenly without talking to the doctor as it may worsen your symptoms. Some common side effects of this medicine constipation, difficulty in urination, weight gain, tiredness, and dryness in mouth. It may also cause dizziness and sleepiness, so do not drive or do anything that requires mental focus until you know how this medicine affects you. This medicine may cause weight gain and to control it, you should exercise regularly and take a balanced diet. Remember to inform the doctor if you develop any unusual changes in mood as this medicine may lead to suicidal thoughts. Before taking this medicine let your doctor know if you suffer from kidney or liver disease. Your doctor should also know about all other medicines you are taking as many of these may make this medicine less effective or change the way it works. Inform your doctor if you are pregnant, planning pregnancy or breastfeeding.
Benefits of Zypentin 400mg/10mg Tablet
Treatment of Neuropathic pain
In Treatment of Neuropathic pain Zypentin 400mg/10mg Tablet is a combination medicine used to treat long-lasting (chronic) pain caused by nerve damage due to diabetes, shingles or spinal cord injury. It reduces pain and its associated symptoms such as mood changes, sleep problems, and tiredness. It is thought to work by interfering with pain signals that travel through the damaged nerves and the brain.
Side Effects of Zypentin 400mg/10mg Tablet
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you're worried about them. ['Difficulty in urination, Weight gain, Sleepiness, Dizziness, Tiredness, Blurred vision, Dryness in mouth, Orthostatic hypotension (sudden lowering of blood pressure on standing), Increased heart rate, Uncoordinated body movements']
Directions for Use
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Zypentin 400mg/10mg Tablet may be taken with or without food, but it is better to take it at a fixed time.
How it works
Zypentin 400mg/10mg Tablet is a combination of two medicines: Gabapentin and Nortriptyline. Gabapentin is an alpha 2 delta ligand which decreases the pain by modulating calcium channel activity of the nerve cells. Nortriptyline is a tricyclic antidepressant which increases the levels of chemical messengers (serotonin and noradrenaline) that stop the movement of pain signals in the brain. Together, they relieve neuropathic pain (pain from damaged nerves).
Alcohol
UNSAFE - Zypentin 400mg/10mg Tablet may cause excessive drowsiness with alcohol.
Pregnancy
CONSULT YOUR DOCTOR - Zypentin 400mg/10mg Tablet may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
Breast feeding
CONSULT YOUR DOCTOR - Zypentin 400mg/10mg Tablet is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
Driving
UNSAFE - Zypentin 400mg/10mg Tablet may cause side effects which could affect your ability to drive. As Zypentin 400mg/10mg Tablet may affect your alertness which may affect your ability to drive.
Kidney
CAUTION - Zypentin 400mg/10mg Tablet should be used with caution in patients with kidney disease. Dose adjustment of Zypentin 400mg/10mg Tablet may be needed. Please consult your doctor.
Liver
CAUTION - Zypentin 400mg/10mg Tablet should be used with caution in patients with liver disease. Dose adjustment of Zypentin 400mg/10mg Tablet may be needed. Please consult your doctor. Inform your doctor if you develop any signs and symptoms of jaundice while taking this medicine. Use of Zypentin 400mg/10mg Tablet is not recommended in patients with severe liver disease.
What If You Forget to take Zypentin 400mg/10mg Tablet?
If you miss a dose of Zypentin 400mg/10mg Tablet, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Storage Advice
Store below 30°C
Manufacturer Address
i - 49, basement, lajpat nagar - ii, new delhi south delhi dl 110024 in
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Disclaimer
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