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Ethambutol + Isoniazid + Pyrazinamide + Rifampicin

Uses

Isoniazid, Rifampicin, Ethambutol, and Pyrazinamide are used in the treatment of tuberculosis.

How it Works

How Isoniazid, Rifampicin, Ethambutol, and Pyrazinamide work: Isoniazid, Rifampicin, Ethambutol, and Pyrazinamide is a combination of four medications.

Side Effects

Common side effects of Isoniazid, Rifampicin, Ethambutol, and Pyrazinamide include nausea, vomiting, peripheral neuropathy (tingling and numbness in the feet and hands), abdominal pain, skin rash, hepatitis (viral infection of the liver), lethargy, low blood platelets, joint pain, thrombocytopenic purpura, cutaneous reactions, and retrobulbar optic neuritis.

Expert Advice

You have been prescribed Isoniazid, Rifampicin, Ethambutol, and Pyrazinamide for the treatment of tuberculosis.
Take the medication on an empty stomach and preferably at the same time every day.
Avoid missing a dose, as this increases the risk of the bacteria becoming resistant to the medication and may also heighten the risk of side effects.
The medication may cause discoloration of your urine, sweat, saliva, and tears, resulting in a reddish/orange color. This is normal and not harmful.
Your doctor may check your liver function before starting treatment and regularly thereafter.
Inform your doctor if you notice any of the following symptoms:
- Yellowing of eyes or skin
- Dark urine
- Stomach pain
Avoid consuming alcohol while taking Isoniazid, Rifampicin, Ethambutol, and Pyrazinamide, as this may increase the risk of liver side effects.
The medication may cause vitamin B6 deficiency. Your doctor may prescribe vitamin B6 supplements to help prevent potential issues related to its deficiency, such as inflammation of the nerves (neuritis).
Use a reliable contraceptive method (such as condoms or a diaphragm) to prevent pregnancy while taking Isoniazid, Rifampicin, Ethambutol, and Pyrazinamide, as it may reduce the effectiveness of hormonal contraceptives like the pill.
Do not take indigestion remedies (antacids) within at least two hours of taking the medication.
Complete the full course of the medication, even if you feel better. Stopping treatment early increases the risk of the infection returning.

Other Combinations

Ethambutol + Isoniazid

Ethambutol + Isoniazid + Piperine + Pyrazinamide + Rifampicin

Ethambutol + Isoniazid + Pyrazinamide + Rifampicin + Vitamin B6 (Pyridoxine)

Ethambutol + Isoniazid + Rifampicin

Ethambutol + Isoniazid + Rifampicin + Vitamin B6 (Pyridoxine)

Related Medications

Salt Composition

Isoniazid NA + Rifampicin NA + Ethambutol NA + Pyrazinamide NA

Coxter Kit 4 Tablet

Alkem Laboratories Ltd

Strip of 4 tablets

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Isoniazid 250mg + Rifampicin 80mg + Ethambutol 120mg + Pyrazinamide NA

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Macleods Pharmaceuticals Pvt Ltd

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₹30.8

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Salt Composition

Isoniazid NA + Rifampicin NA + Ethambutol NA + Pyrazinamide NA

Coxwin 4FD Tablet

Marc Laboratories Pvt Ltd

Strip of 6 tablets

₹45.1

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Salt Composition

Isoniazid 75mg + Rifampicin 150mg + Ethambutol 275mg + Pyrazinamide 400mg

MONITOR 4 TABLET

Shreya Life Sciences Pvt Ltd

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₹11.9

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Scc 4 LW Plus Pouch

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Packet of 1 Pouch

₹23.1

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Salt Composition

Isoniazid 150mg + Rifampicin 225mg + Ethambutol 400mg + Pyrazinamide 750mg

Strip of 6 tablets

₹435

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Salt Composition

Isoniazid NA + Rifampicin NA + Ethambutol NA + Pyrazinamide NA

Maneesh Pharmaceuticals Ltd

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₹10.5

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Salt Composition

Isoniazid 300mg + Rifampicin 450mg + Ethambutol 800mg + Pyrazinamide 750mg

Sunij Pharma Pvt Ltd

Packet of 4 kit

₹13.6

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Salt Composition

Isoniazid 150mg + Rifampicin 225mg + Ethambutol 400mg + Pyrazinamide 750mg

Vicox EZ Tablet

Shrinivas Gujarat Laboratories Pvt Ltd

Strip of 6 tablets

₹55.2

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Salt Composition

Isoniazid 75mg + Rifampicin 150mg + Ethambutol 275mg + Pyrazinamide 400mg

Coxcure 4 Tablet

Alpic Remedies Ltd

Strip of 10 tablets

₹58

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Salt Composition

Isoniazid 150mg + Rifampicin 225mg + Ethambutol 800mg + Pyrazinamide 225mg

Shreya Life Sciences Pvt Ltd

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₹14.7

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Salt Composition

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Coxina 4 Tablet

Aristo Pharmaceuticals Pvt Ltd

Strip of 3 tablets

₹11.6

Sorry, Substitute Medicine is Unavailable

Salt Composition

Isoniazid NA + Rifampicin NA + Ethambutol NA + Pyrazinamide NA

Aristo Pharmaceuticals Pvt Ltd

Packet of 4 kit

₹11.3

Sorry, Substitute Medicine is Unavailable

Salt Composition

Isoniazid 100mg + Rifampicin 150mg + Ethambutol 275mg + Pyrazinamide 500mg

Forecox 150 Tablet

Macleods Pharmaceuticals Pvt Ltd

Strip of 6 tablets

₹59.1

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Salt Composition

Isoniazid 75mg + Rifampicin 150mg + Ethambutol 275mg + Pyrazinamide 400mg

Mycurit 4 mg Tablet

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Strip of 6 tablets

₹34.4

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Salt Composition

Isoniazid NA + Rifampicin NA + Ethambutol NA + Pyrazinamide NA

Stanex 4 Tablet

Stanford Biotech Pvt Ltd

Strip of 6 tablets

₹41.1

Sorry, Substitute Medicine is Unavailable

Salt Composition

Isoniazid 150mg + Rifampicin 225mg + Ethambutol 400mg + Pyrazinamide 750mg

R-Cinex EZ Tablet

Strip of 6 tablets

₹82

Sorry, Substitute Medicine is Unavailable

Frequently asked questions

How should I take Isoniazid, Rifampicin, Ethambutol, and Pyrazinamide?

Take Isoniazid, Rifampicin, Ethambutol, and Pyrazinamide on an empty stomach, at least one hour before or two hours after a meal, with a full glass of water.

Can Isoniazid, Rifampicin, Ethambutol, and Pyrazinamide affect my vision?

Yes, Ethambutol may cause visual impairment. Inform your doctor immediately if you notice any changes in your eyesight.

Does Isoniazid, Rifampicin, Ethambutol, and Pyrazinamide cause urine discoloration?

Yes, Rifampicin can cause temporary discoloration of urine, sweat, saliva, and tears (red, orange, or brown). However, if urine discoloration is accompanied by stomach pain, loss of appetite, or jaundice, contact your doctor as it may indicate liver damage.

Is it safe to drink alcohol while taking Isoniazid, Rifampicin, Ethambutol, and Pyrazinamide?

No, avoid alcohol while taking these medications as it increases the risk of hepatitis associated with Isoniazid.

Can I use oral contraceptives while taking Isoniazid, Rifampicin, Ethambutol, and Pyrazinamide?

No, these medications may reduce the effectiveness of birth control pills. Consult your doctor for alternative contraceptive methods that do not affect hormone levels.

Is it safe to stop taking Isoniazid, Rifampicin, Ethambutol, and Pyrazinamide if I feel better?

No, do not discontinue these medications without consulting your doctor, as stopping early can worsen your infection and lead to drug-resistant tuberculosis.

What are the storage and disposal instructions for Isoniazid, Rifampicin, Ethambutol, and Pyrazinamide?

Store the medicine in its original container, tightly closed, and follow the storage instructions on the label. Dispose of any unused medicine safely to prevent accidental ingestion by pets, children, or others.

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